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4 edition of Differential regulation of matrix metalloproteinase-2 (MMP-2) by phorbol myrisate acetate, and by DL-[alpha]-difluoromethylornithine, in cell lines of varying tumorigenic and metastatic potential found in the catalog.

Differential regulation of matrix metalloproteinase-2 (MMP-2) by phorbol myrisate acetate, and by DL-[alpha]-difluoromethylornithine, in cell lines of varying tumorigenic and metastatic potential

Oliver Yeung

Differential regulation of matrix metalloproteinase-2 (MMP-2) by phorbol myrisate acetate, and by DL-[alpha]-difluoromethylornithine, in cell lines of varying tumorigenic and metastatic potential

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  • 19 Currently reading

Published by National Library of Canada in Ottawa .
Written in English


Edition Notes

Thesis (M.Sc.) -- University of Toronto, 1999.

SeriesCanadian theses = -- Thèses canadiennes
The Physical Object
FormatMicroform
Pagination2 microfiches : negative. --
ID Numbers
Open LibraryOL19264934M
ISBN 100612460568
OCLC/WorldCa47365013

Thrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene.. Thrombospondin 1 is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/betaAliases: THBS1, THBS, THBS-1, TSP, TSP-1, . matrix metalloproteinases (MMPs), which include the collagenases, stromelysins, gelatinases, and membrane-type MMPs (MT-MMP), are a family of structurally related zinc-dependent proteases that are involved in cellular infiltration, cytokine activation, cell migration, tissue damage, remodeling, and repair (3, 36).MMPs are central to the regulation of extracellular matrix Cited by: @article{osti_, title = {Differential roles of HIC-5 isoforms in the regulation of cell death and myotube formation during myogenesis}, author = {Zhengliang, Gao and Deblis, Ryan and Glenn, Honor and Schwartz, Lawrence M and Biology Department, University of Massachusetts, Amherst, MA and Pioneer Valley Life Sciences Institute, Springfield, MA }, . Activity of Matrix Metalloproteinase 2 and 9 in Follicular Fluid and Seminal Plasma and Its Relation to Embryo Quality and Fertilization Rate This year MMP opened a dedicated lettings office at Back Lane in Newtown, where it lets and manages a portfolio of nearly properties in mid Wales and Shropshire.


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Differential regulation of matrix metalloproteinase-2 (MMP-2) by phorbol myrisate acetate, and by DL-[alpha]-difluoromethylornithine, in cell lines of varying tumorigenic and metastatic potential by Oliver Yeung Download PDF EPUB FB2

Differential regulation of matrix metalloproteinase-2 and -9 expression and activity in adult rat cardiac fibroblasts in response to interleukin-1beta. Xie Z(1), Singh M, Singh K. Author information: (1)Department of Physiology, James H Quillen College of Medicine, James H Quillen Veterans Affairs Medical Center, East Tennessee State University Cited by:   The differential regulation of MMP‐2 and Differential regulation of matrix metalloproteinase-2 book, therefore, may be a useful therapeutic target in the treatment of RA.

Activated protein C (APC) is a natural anticoagulant derived from its vitamin K–dependent plasma precursor protein C.

Activation of protein C occurs on the endothelial cell surface and is triggered by a complex formed between thrombin and Cited by:   The differential effects of PKC isoforms on the regulation of MAPK activity in different cell types may reflect differences in activation of different isoforms of PKC and their downstream coupling.

Of note, IL-1β has been shown to activate ERK1/2, JNKs, and p38 kinase via PKC-independent pathways in intestinal myofibroblasts (40).Cited by: Differential regulation of matrix metalloproteinase 2 and matrix metalloproteinase 9 by activated protein C: Relevance to inflammation in rheumatoid arthritis.

Differential Regulation of Matrix Metalloproteinase-2 and -9 Expression and Activity in Adult Rat Cardiac Fibroblasts in Response to Interleukin-1 October. Differential regulation of matrix metalloproteinase-2 activation in human breast cancer cell lines Erik W.

() Differential regulation of matrix metalloproteinase-2 activation in human breast cancer cell lines. Annals of Differential regulation of matrix metalloproteinase-2 book New York Academy of Sciences,pp.

View at publisher Impact and interest: 0 citations in Scopus. 6 Cited by: 6. Read "Differential regulation of matrix metalloproteinase 2 and matrix metalloproteinase 9 by activated protein C: Relevance to inflammation in rheumatoid arthritis, Arthritis & Rheumatology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

Differential regulation of matrix Differential regulation of matrix metalloproteinase-2 book and -9 expression and activity in adult rat cardiac fibroblasts in response to interleukin-1beta. (PMID) PMIDCited by: Matrix metalloproteinases (MMPs) are a group of proteinases that degrade components of the extracellular matrix (ECM).

There is increasing evidence for a link between the activation of MMPs and Alzheimer's disease (AD) pathogenesis, in which both beneficial and detrimental actions of MMPs have Differential regulation of matrix metalloproteinase-2 book by: Regulation of matrix metalloproteinase 2 by oligomeric amyloid β protein Article in Brain research March with 34 Reads How we measure 'reads'.

Matrix metalloproteinases (MMPs) are a major group of enzymes that regulate cell-matrix composition. MMP genes show a highly conserved modular structure. Ample evidence exists on the role of MMPs in normal and pathological processes, including Differential regulation of matrix metalloproteinase-2 book, wound healing, inflammation, arthritis, cardiovascular diseases, pulmonary diseases and by: Fig 1.

Effect of doxycycline on matrix metalloproteinase-2 (MMP-2) production from cultured aortic smooth muscle cells (SMCs).

Aortic SMCs cultured in either serum-free M (Control) or macrophage or lymphocyte co-culture medium (Stimulated) were treated with doxycycline at indicated concentrations for 24 by: Matrix metalloproteinase-2 (MMP-2), previously named 72 kDa type IV collagenase or gelatinase A, belongs to the MMP family of calcium and zinc-dependent endopeptidases.

MMPs were originally considered to be secreted proteases which play a major role in degrading extracellular matrix (ECM) proteins.

Differential regulation of matrix metalloproteinase-2 activation in human breast cancer cell lines. MMP-2 activity increased 71% (n = 5, P β-galactosidase activity showed a fold (n = 8, P MMP-2 transcription at day 3 and day 8, by: 72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene.

The MMP2 gene is located on chromosome 16 at position The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory s: MMP2, CLG4, CLG4A, MMP-2, MMP-II. Up-regulation of matrix metalloproteinase-2 (MMP-2) expression and down-regulation of extracellular signal-regulated kinase (ERK) activity in human uterine leiomyoma.

Protein and mRNA were extracted from human myometrium (HM) and matched uterine leiomyoma (HL) tissues for western blot and real-time qPCR (RT–qPCR) by: Background and Aims.

Matrix metalloproteinase-2 (MMP-2), a type IV collagenase secreted by activated hepatic stellate cells (HSCs), is upregulated in chronic liver disease and is considered a profibrotic mediator due to its proliferative effect on cultured HSCs and ability to degrade normal liver by: Differential regulation of gelatinase A and B and TIMP-1 and -2 by TNFα and HIV virions in astrocytes especially through the production of matrix metalloproteinase-2 A.

Pagenstecher, A.K. Stalder, C.L. Kincaid, S.D. Shapiro, I.L. CampbellDifferential expression of matrix metalloproteinase and tissue inhibitor of matrix Cited by: Differential regulation of platelet aggregation by matrix metalloproteinases-9 and Fernandez-Patron C(1), Martinez-Cuesta MA, Salas E, Sawicki G, Wozniak M, Radomski MW, Davidge ST.

Author information: (1)Perinatal Research Centre, Department of Obstetrics/Gynaecology, University of Alberta, Edmonton, by: Expression of Matrix Metalloproteinase-2 and -9 and Their Inhibitors in Peripheral Blood Cells of Patients with Chronic Hepatitis C Article (PDF Available) in Clinical Chemistry 46(2) Ensembl ENSG ENSMUSG UniProt P P RefSeq (mRNA) NM_ NM_ RefSeq (protein) NP_ n/a Location (UCSC) Chr – Mb Chr – Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tissue inhibitor of metalloproteinases 2 (TIMP2) is a gene and a Aliases: TIMP2, CSCK, DDC8, TIMP.

Introduction. Alteration in the expression of extracellular matrix metalloproteinase inducer (EMMPRIN), matrix metalloproteinase-2 (MMP-2), tissue inhibitors of matrix metalloproteinases (TIMP-2) and platelet derived growth factor (PDGF-AA) Cited by:   Katsuhiko Naruse, Gendie E.

Lash, Barbara A. Innes, Harry A. Otun, Roger F. Searle, Stephen C. Robson, Judith N. Bulmer, Localization of matrix metalloproteinase (MMP)-2, MMP-9 and tissue inhibitors for MMPs (TIMPs) in uterine natural killer cells in early human pregnancy, Human Reproduction, Vol Issue 3, MarchPages – Cited by:   These observations demonstrate the complex reciprocal effects of ERK1/2 and p38 MAPK in the regulation of MMP activity, which could complicate the use of MAPK-specific inhibitors as therapeutic agents to down-regulate the biologic effects of TGF-beta1 on pericellular collagen degradation and tumor by:   Vascular matrix metalloproteinase (MMP)-2 activity was higher, but MMP-1 levels were significantly reduced in GK rats, and MMP levels were restored to control levels by ETA receptor antagonism.

We conclude that ET-1 promotes cerebrovascular remodeling in type 2 diabetes through differential regulation of by: Matrix metallopeptidases (MMPs), also known as matrix metalloproteinases or matrixins, are metalloproteinases that are calcium-dependent zinc-containing endopeptidases; other family members are adamalysins, serralysins, and MMPs belong to a larger family of proteases known as the metzincin ro: IPR   Hepatic fibrosis is the result of an imbalance between enhanced matrix synthesis and diminished breakdown of connective tissue proteins, the net result of which is increased deposition of extracellular matrix.

In this concept, MMPs play an important role because their activity is largely responsible for matrix breakdown (9,10). Differential effects of tumor necrosis factor- on matrix metalloproteinase-2 expression in human myometrial and uterine leiomyoma smooth muscle cells.

Differential Regulation of Matrix Metalloproteinase-2 and -9 Expression and Activity in Adult Rat Cardiac Fibroblasts in Response to Interleukin-1β 21 July | Journal of Biological Chemistry, Vol.

No. 38Cited by: Upregulation of MMP-2 and MMP-9 in diabetes leads to disruption of extracellular matrix and thus causes complications of diabetes. Matrix metalloproteinase 2 and 9 can be potential targets to treat cardiovascular complications of : Lokesh Kumar Bhatt, Veeranjaneyulu Addepalli.

Matrix metalloproteinases (MMP) are involved in the pathophysiology of brain injury. We recently showed that knockout mice deficient in MMP-9 expression were protected against traumatic brain injury.

However, the cellular sources of MMP activity after trauma remain to be fully defined. In this study, we investigated the hypothesis that resident brain cells secrete MMP after Cited by:   Matrix metalloproteinases: biologic activity and clinical implications. J Clin Oncol. Mar; 18 (5)– Deryugina EI, Bourdon MA, Reisfeld RA, Strongin A.

Remodeling of collagen matrix by human tumor cells requires activation and cell surface association of matrix metalloproteinase Cancer Res. Aug 15; 58 (16)–Cited by: Additionally, B. nigra extract suppressed the migratory and invasive properties of both cell lines, downregulated the expression of matrix metalloproteinase-2 (MMP2), MMP9, and Snail and upregulated the expression of E-cadherin at mRNA and protein levels.

Robbins JR, McGuire PG, Wehrle-Haller B, Rogers SL () Diminished matrix metalloproteinase 2 (MMP-2) in Ectomesenchyme-derived tissues of the patch mutant mouse: regulation of MMP-2 by PDGF and effects on mesenchymal cell migration.

Dev Biol – PubMed CrossRef Google ScholarCited by: 1. Abstract. Matrix metalloproteinase 2 (MMP2) is important in breast cancer (BC) invasion and metastasis. In order to study the expression of MMP2, in breast cancer brain metastasis, we used a syngeneic rat model of distant metastasis of ENU, a carcinogen-induced mammary adenocarcinoma cell by: 1.

Ensembl ENSG n/a UniProt P O RefSeq (mRNA) NM_ NM_ RefSeq (protein) NP_ NP_ Location (UCSC) Chr – Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse Matrix metalloproteinase 15 also known as MMP15 is an enzyme that in humans is encoded by the MMP15 gene.

Aliases: MMP15, MT2-MMP, MTMMP2, SMCP-2. Type IV collagenase, kD, is officially designated matrix metalloproteinase-2 (MMP2). It is also known as gelatinase, kD (Nagase et al., ).Type IV collagenase is a metalloproteinase that specifically cleaves type IV collagen, the major structural component of basement membranes (, ).The metastatic potential of tumor cells has been found to correlate with the.

56 Xie Z, Singh M, Singh K. Differential regulation of matrix metalloproteinase-2 and -9 expression and activity in adult rat cardiac fibroblasts in response to interleukin-1beta. J Biol Chem –, Crossref PubMed ISI Google ScholarCited by:   Members of MMP, a family of proteolytic enzymes, mediate the turnover of extracellular matrix components and are inhibited by TIMPs.

6, 17 Remodelling of the atrial extracellular matrix, manifested by selective down-regulation of TIMP-2 expression and up-regulation of MMP-2 expression, has been associated with the development of sustained by:.

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ENGINEERING MATHEMATICS 2 MA Notes pdf free download. OBJECTIVES: MA Notes ENGINEERING MATHEMATICS 2 This course is designed to cover topics such as Matrix Algebra, Vector Calculus, Complex Analysis and Laplace Transform.Purchase Matrix Metalloproteinases - 1st Edition.

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